In conclusion, tamarins may represent a model of early AD pathology. Phospho-tau labeled dystrophic neurites and tangles, typically present in human AD, were absent in the tamarins. Vascular A β was detected in 14 of the 20 aged tamarins A β42 preceded A β40 deposition. Plaques contained mainly A β42, and in the oldest animals, were associated with reactive astrocytes, activated microglia, Apo E, and ubiquitin-positive dystrophic neurites, similar to human plaques. This model is compatible with the original discoveries of the transition near 64 K, first by Haga et al. A β plaque deposition was observed in 16 of the 20 oldest tamarins (>12 years). We performed detailed immunohistochemical analyses of A β deposition and associated pathogenesis in archived brain sections from 36 tamarins ranging in age from 6–21 years. Typical lifespan is 13–14 years of age in the wild and 15–20+ years in captivity. Here we report, for the first time, age-related neuropathological changes in cotton-top tamarins (CTT, Saguinus oedipus), an endangered non-human primate native to the rainforests of Colombia and Costa Rica. Cerebral A β deposition has been reported previously for rhesus monkeys, vervets, squirrel monkeys, marmosets, lemurs, cynomologous monkeys, chimpanzees, and orangutans. The amyloid precursor protein and its shorter fragment, A β, are homologous between humans and non-human primates. Numerous other proteins are associated with plaques in human AD brain, including Apo E and ubiquitin.
Megumi is one of the veterans of the Japanese entertainment industry having done modeling for quite a while. She is really beautiful just like gravure model and actress Yoko Mitsuya, the awesome supermodel from Saitama. In addition, activated microglia and reactive astrocytes are often associated with plaques and tangles. Megumi Yasu is a Japanese supermodel or gravure idol and actress. Two major neuropathological hallmarks of AD include cerebral deposition of amyloid-beta protein (A β) into plaques and blood vessels, and the presence of neurofibrillary tangles in brain.
Alzheimer's disease (AD) is the most common progressive form of dementia in the elderly.
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